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oai:ojs.www.eurjchem.com:article/1423 2016-06-30T06:25:29Z eurjchem:ART driver

Synthesis and HPLC resolution of isomers of novel phosphorus fluorinated 2,4,6-trimethylphenylazo pyridines Hacini, Zineb Sekhri, Lakhdar Isomers Synthesis HPLC resolution Chiralcel OD-H column Phosphorus fluorinated X-Ray single crystal structure New compounds of phosphorus fluorinated 2,4,6-trimethylphenylazo pyridines (4a-c) have been synthesized in high yields via adding n-butyl lithium in hexane to a stirred solution of methyldiphenylphosphine oxide in dry THF at 0 °C, then cooled to around -78 °C, treated with azo-pyridines(2a-c) and then allowed to warm at room temperature over 2 h. The isomers of (E)-((5-chloro-3,6-difuoro-4-(mesityldiazenyl)pyridin-2-yl)methyl)diphenyl phosphine oxide (4b) and (E)-((3,6-difuoro-4-(mesityldiazenyl)5-methoxypyridin-2-yl)methyl)diphenyl phosphine oxide (4c) can be separated on analytical HPLC: Chiralcel OD-H column, hexane:2-PrOH, (9:1, v:v) mobile phase, flow-rate, 1.0 mL/min, 25 °C, λ = 254 nm and polarimetric detection, 20 µL injection volume. The resolution of this isomers were 2.12, 1.84, respectively. Atlanta Publishing House LLC 2016-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1423 10.5155/eurjchem.7.2.225-229.1423 European Journal of Chemistry; Vol. 7 No. 2 (2016): June 2016; 225-229 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1423/pdf_1423