2026-05-26T16:46:50Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1473 2016-09-30T03:57:42Z eurjchem:ART driver

Pressure as effective green technology for synthesis of polyfunctionally substituted heteroaromatics: Synthesis of a variety of pyrazolo[1,5-a]pyrimidines AlMarzouq, Douaa Salman Zaky, Omniya Sayed AlNajjar, Abdulaziz Abdulrazaq Sadek, Kamal Usef Q-tube High yields Record time Green technology Pyrazolo[1 5-a]pyrimidines Reactions under increased pressure Pyrazole molecules are in the forefront of organic chemistry due to their various encompass substituents, which have many biological activity sequence. The biological and medicinal activities of pyrazolo[1,5-a]pyrimidines have received considerable interest in this regard. We reported here a comparison between reaction of 4-phenylazo-3,5-diaminopyrazole (4) with ethyl propiolate (15), dimethylacetylene dicarboxylate (20), diethyl fumarate (25) and benzylidenemalononitrile (11) in the presence of catalytic amount of piperidine. We initially followed literature procedure (method A), then utilizing ultrasound irradiation (method B), microwave heating (method C) and in a Q-tube (method D). We confirmed the structure of the product by analytical spectroscopic methods. Method (D) gave a good yield with a record reaction time. Atlanta Publishing House LLC 2016-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1473 10.5155/eurjchem.7.3.347-351.1473 European Journal of Chemistry; Vol. 7 No. 3 (2016): September 2016; 347-351 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1473/pdf_1473