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oai:ojs.www.eurjchem.com:article/1474 2016-09-30T03:57:42Z eurjchem:ART driver

One-pot pseudo five-component synthesis and antioxidant evaluation of 4,4'-(aryl-methylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol) Gouda, Moustafa Ahmed Al‐Balawi, Majed Musallam Mutlaq Abu-Hashem, Ameen Ali Arylmethylene Bis-pyrazol-5-ol Michael reaction One pot reaction Antioxidant activity Tandem Knoevenagel reaction A simple method for the synthesis of some 4,4'-(aryl-methylene)bis(3-methyl-1H-pyrazol-5-ol) derivatives via a one-pot pseudo five-component reaction of phenyl hydrazine, ethyl acetoacetate and aldehydes in acetic acid is reported. The prepared compounds were characterized by elemental analyses and spectral data. Some of the synthesized compounds were screened for their antioxidant activity using 2,2'-azino-bis(3-ethyl benzothiazoline-6-sulfonic acid (ABTS) method; all the investigated compounds showed similar and higher antioxidant activity than ascorbic acid and exhibited high protection against DNA damage induced by the bleomycin iron complex. Atlanta Publishing House LLC 2016-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1474 10.5155/eurjchem.7.3.363-367.1474 European Journal of Chemistry; Vol. 7 No. 3 (2016): September 2016; 363-367 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1474/pdf_1474