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oai:ojs.www.eurjchem.com:article/1505 2016-12-31T08:51:22Z eurjchem:ART driver

Synthesis, characterization, anticancer activity, optical spectroscopic and docking studies of novel thiophene-2-carboxaldehyde derivatives Shareef, Mohamed Ahadu Musthafa, Mohamed Velmurugan, Devadasan Karthikeyan, Subramani Ganesan, Singaravelu Padusha, Syed Ali Musthafa, Saiyad Mohamed, Jamal Molecular docking Anticancer activity Drug binding pocket Antimicrobial activity Hydrophobic interaction Fluorescence resonance energy transfer 2-((4-Methylpiperazin-1-yl)(thiophen-2-yl)methyl)hydrazinecarboxamide (L1) and (2-(piperazin-1-yl(thiophen-2-yl)methyl)hydrazinecarboxamide (L2) from the family of thiophene-2-carboxaldehyde derivatives have been synthesized. These new compounds have good antibacterial as well as antifungal activity and also less toxic in nature. Exemplary binding characteristics of these novel compounds and pharmacokinetic mechanism were confirmed by optical spectroscopic, anticancer and docking studies. The binding of thiophene-2-carboxaldehyde derivatives to carrier protein, Human Serum Albumin (HSA) has been investigated by studying its quenching mechanism, binding kinetics and the molecular distance (r) between donor (HSA) and acceptor (thiophene-2-carboxaldehyde derivatives) according to Forster’s theory of non-radiative energy transfer (FRET). The micro environment of HSA has also been studied by using synchronous fluorescence spectroscopy technique and the molecular docking technique has been used to explore the hydrogen bonding, hydrophobic interaction between the human serum albumin with L1 and L2 compound. Atlanta Publishing House LLC 2016-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1505 10.5155/eurjchem.7.4.454-462.1505 European Journal of Chemistry; Vol. 7 No. 4 (2016): December 2016; 454-462 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1505/pdf_1505