2026-05-09T16:37:32Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1522 2017-03-31T07:00:46Z eurjchem:ART driver

Synthesis of 3H-imidazo[4,5-b] pyridine with evaluation of their anticancer and antimicrobial activity Shelke, Rohini Narayan Pansare, Dattatraya Navnath Pawar, Chandrakant Dhondiram Deshmukh, Arun Khandu Pawar, Rajendra Pandu Bembalkar, Saroj Ram Anticancer activity Substituted aldehydes Antimicrobial activity Conventional synthesis Microwave-assisted synthesis 5-Bromopyridine-2 3-diamine Microwave assisted and conventional synthetic methods of new 6-bromo-2-(substituted)-3H-imidazo[4,5-b]pyridine and its derivatives are described, which were obtained in reduced reaction times, higher yields, cleaner reactions than previously described methods. All the synthesized compounds were characterized, and screened for their anticancer and antimicrobial activity. Among synthesized compounds 3b and 3k shows prominent antibacterial activity and compound 3f shows both antibacterial and antifungal activity. Compounds 3h and 3j shows prominent anticancer activity against the both breast cancer cell lines, MCF-7 and BT-474. These results suggest that the imidazo[4,5-b]pyridine moiety may serve as a new promising template for synthesis of anticancer and antimicrobial agents and further study is required for evaluation of their mechanism of action. Atlanta Publishing House LLC 2017-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1522 10.5155/eurjchem.8.1.25-32.1522 European Journal of Chemistry; Vol. 8 No. 1 (2017): March 2017; 25-32 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1522/pdf_1522