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oai:ojs.www.eurjchem.com:article/1535 2017-03-31T07:00:46Z eurjchem:ART driver

Pharmacological evaluation of ONNO donor quadridentate Schiff bases Shabbir, Muhammad Akhter, Zareen Ashraf, Ahmad Raza Bolte, Michael Wahid, Sumbal Mirza, Bushra Schiff bases Crystal structure Cytotoxic activities Antitumor activities Antibacterial activity Pharmacological evaluation Four ONNO donor Schiff bases 2-((E)-(2-((E)-2-hydroxybenzylideneamino)ethylimino) methyl)phenol (H2L1), 2-((E)-(2-((E)-2-hydroxybenzylideneamino)propylimino)methyl) phenol (H2L2), 2-((E)-1-(2-((E)-1-(2-hydroxyphenyl) ethylideneamino)ethylimino)ethyl) phenol (H2L3) and 2-((E)-1-(2-((E)-1-(2-hydroxyphenyl)ethylideneamino)propylimino) ethyl)phenol (H2L4) were synthesized by the reactions of ethylene/propylene diamines with 2-hydroxy benzaldehyde/2-hydroxy acetophenone. The new compounds were characterized by FT-IR and NMR (1H and 13C) spectroscopic techniques accompanied by elemental, GC/MS and single crystal X-ray diffraction analyses. These compounds were screened for various biological studies i.e. brine shrimp cytotoxic, antitumor and antibacterial activities The compound H2L3 showed highest cytotoxic and antitumor activities with lowest LD50 (14.27) and IC50 values (18.90). All the compounds were highly active in protecting DNA against hydroxyl free radicals. Antibacterial studies had shown that these were inactive against Gram positive bacteria (Staphylococcus aureus and Micrococcus luteus) while active against Gram negative bacteria (Enterobacter aerogenes, Bordetella bronchiseptica and Salmonella typhi) showing variable antibacterial activity. Atlanta Publishing House LLC 2017-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/1535 10.5155/eurjchem.8.1.46-51.1535 European Journal of Chemistry; Vol. 8 No. 1 (2017): March 2017; 46-51 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1535/pdf_1535 https://www.eurjchem.com/index.php/eurjchem/article/view/1535/2589