2026-05-25T00:45:49Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1540 2017-03-31T07:00:46Z eurjchem:ART driver

Synthesis, antibacterial activities and phospholipid membrane interactions of novel dialkyl 2,2’-disulfanediyldibenzoates Laulloo, Sabina Jhaumeer Bhowon, Minu Gupta Akerman, Matthew Joondan, Nausheen Momus, Marie Jessika Lipophilicity Dithiosalicylic acid Dithio-bis-benzoates Antibacterial activity Phospholipid binding X-ray crystallography A series of dialkyl 2,2’-disulfanediyldibenzoates with alkyl chain length C8 to C12 were synthesized and characterized by spectral studies. The structure of compound 3 was also confirmed by X-ray crystallography. The compounds were found to possess good antibacterial activity, especially with respect to Gram positive bacteria, and the activity was found to increase with concomitant increase in chain length. Binding studies of compound 3 with the synthetic phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) showed that the compound interacts with biological membrane mainly via hydrophobic interactions. Atlanta Publishing House LLC 2017-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/1540 10.5155/eurjchem.8.1.60-65.1540 European Journal of Chemistry; Vol. 8 No. 1 (2017): March 2017; 60-65 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1540/pdf_1540 https://www.eurjchem.com/index.php/eurjchem/article/view/1540/2590