2026-05-13T14:59:56Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1542 2017-03-31T07:00:46Z eurjchem:ART driver

Synthesis and characterization of new imidazolidineiminothione and bis-imidazolidineiminothione derivatives as potential antimicrobial agents Ammar, Yousry Ahmed Abbas, Samir Youssef El-Sharief, Marwa Ahmed Mohamed Shehab Salem, Mohamed Abd El-Rashid Mohamed, Ahmed Ragab Cycloaddition Antifungal activity Antibacterial activity Imidazolidine iminothiones N-Arylcyanothioformanilides Bis-Imidazolidine iminothiones A series of new imidazolidineiminothiones (2-4) and bis-imidazolidineiminothiones (5) were synthesized through the cycloaddition reaction of N-arylcyanothioformamides (1) with some electrophilic reagents. Structure of imidazolidineiminothione derivatives were established based on spectroscopic IR, 1H NMR, 13C NMR, MS and elemental analyses data. These compounds were screened for their antibacterial and antifungal activities. Among the synthesized compounds, imidazolidineiminothione derivative 3a showed about 25% less potent effect than Ampicillin against S. epidermidis and B. subtilis (MIC, 0.49 μg/mL) and about 50 % less potent effect than Amphotericin B against A. clavatus and G. Candidum. Bis-imidazolidineiminothione derivative 5a was equipotent to the Gentamycin in inhibiting the growth of N. gonorrhoeae (MIC, 0.49 μg/mL), and displayed 50% less active than Amphotericin B against A. clavatus. Atlanta Publishing House LLC 2017-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1542 10.5155/eurjchem.8.1.76-81.1542 European Journal of Chemistry; Vol. 8 No. 1 (2017): March 2017; 76-81 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1542/pdf_1542