2026-04-30T13:19:03Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1543 2017-04-03T09:01:12Z eurjchem:ART driver

One-pot synthesis and antimicrobial activity of new 4,6-disubstituted-3,4-dihydropyrimidine-2(1H)-thiones Al-Refai, Mahmoud Ibrahim, Mohammad Al-Fawwaz, Abdullah Geyer, Armin Thione Thiourea Pyrimidine Thiophene Pyrimidine-2-thione Antimicrobial activity A series of 3,4-dihydropyrimidine-2(1H)-thiones (3a-i) were synthesized in moderate yields via a one-pot reaction of 3-acetyl-2,5-diclorothiophene (1), aryl aldehydes (2a-i) and thiourea in methanolic solution of potassium hydroxide under reflux conditions. All newly synthesized compounds were characterized by extensive NMR analysis, including 1D NMR experiments (1H and 13C) and 2D NMR experiments (COSY, HMBC and HSQC), as well as ESI-MS and HRESI-MS data. The antimicrobial activity of all new compounds (3a-f) was tested against bacteria and fungi. Thione derivative (3c) only showed activity against Staphylococcus aureus, Bacillus subtilis and Aspergillus niger. Atlanta Publishing House LLC 2017-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1543 10.5155/eurjchem.8.1.96-100.1543 European Journal of Chemistry; Vol. 8 No. 1 (2017): March 2017; 96-100 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1543/pdf_1543 https://www.eurjchem.com/index.php/eurjchem/article/view/1543/2591