2026-05-15T22:40:07Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1553 2017-06-30T04:23:02Z eurjchem:ART driver

A new facile and efficient synthesis of 2-((5-aryl-1,3,4-oxadiazol-2-yl) methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives Kethireddy, Shashikala Kotakommula, Hemalatha Eppakayala, Laxminarayana Mariganti, Thirumala Chary Tetrazole Quinoxalines Antiviral activity 1 3 4-Oxadiazole Antibacterial activity Anticonvulsant activity Newly synthesized compounds containing quinoxaline ring fused with tetrazoles and oxadiazoles show array of pharmacological activities, especially, anti-inflammatory, analgesic and anticonvulsant activities. The ability to serve as surrogates or bioisosteres for carboxylic acids, esters and carboxamides made them important moieties in drug designing. Considering the importance of quinoxalines, tetrazoles and 1,3,4-oxadiazoles to both medicinal and heterocyclic chemistry, the following 2-((5-aryl-1,3,4-oxadiazol-2-yl)methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives are synthesized. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR and Mass spectral data. All the synthesized derivatives were tested in vitro for their antibacterial activity. Atlanta Publishing House LLC 2017-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1553 10.5155/eurjchem.8.2.125-129.1553 European Journal of Chemistry; Vol. 8 No. 2 (2017): June 2017; 125-129 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1553/pdf_1553