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oai:ojs.www.eurjchem.com:article/1565 2017-06-30T04:23:02Z eurjchem:ART driver

Some new [(chromen-4-ylamino)-ethyl]-azetidin-2-ones and their antibacterial activity Hoti, Ramiz Troni, Naser Ismaili, Hamit Mulliqi-Osmani, Gjyle Thaçi, Veprim Coumarin Schiff bases Azetidin-2-one Benzopyran-2-one Antibacterial activity Catalytic condensation A series of new azetidin-2-ones, on the basis of 3-nitrobenzopyran-2-one were synthesized by cyclo-condensation of various Schiff bases of coumarin with acetyl chloride. 4-(2-Amino-ethylamino)-3-nitro-chromen-2-one (3) is synthesized by condensation of 4-chloro-3-nitrobenzopyran-2-one (2) and ethane-1,2-diamine. The catalytic condensation of compound 3 with benzaldehyde, salicylaldehyde or 3-nitrobenzaldehyde yielded corresponding 4-[4-(benzylidene-amino)-phenylamino]-3-nitrobenzopyran-2-ones, 4a-c. The cyclization reac-tion of compounds 4a-c with acetyl chloride yielded corresponding substituted azetidin-2-ones, 5a-c. The structures of the obtained compounds were established by FT-IR and NMR spectrometric data and their elemental analysis. Prepared compounds 4a-c and 5a-c were screened for their antibacterial activity against S. aureus, E. coli and Klebsiella by disc diffusion method. Compounds 4a-c exhibited moderate antibacterial activity, whereas compounds 5a-c displayed significant activity against these microorganisms. The impact of substitutions in antimicrobial activity was also explored. Atlanta Publishing House LLC 2017-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1565 10.5155/eurjchem.8.2.183-187.1565 European Journal of Chemistry; Vol. 8 No. 2 (2017): June 2017; 183-187 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1565/pdf_1565