2026-05-09T17:32:34Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1574 2017-09-30T11:59:49Z eurjchem:ART driver

Two spectrophotometric methods for the determination of azithromycin and roxithromycin in pharmaceutical preparations Ibrahim, Fawzia Ahmed Wahba, Mary Elias Kamel Galal, Galal Magdy Macrolides Azithromycin Metal complex Roxithromycin Spectrophotometry N-Bromosuccinimide Two new and simple spectrophotometric procedures have been proposed and validated for estimation of two important macrolide antibiotics namely, azithromycin dihydrate and roxithromycin. Method I depends on complex formation between any of the two drugs and copper in acidic medium where the absorbances of the produced complexes are measured at 250 and 264 nm with linearity ranges of 1.0-100.0 and 2.0-130.0 µg/mL for the two drugs, respectively. Method II depends on the reaction of these drugs with N-bromosuccinimide forming a product which is yellow colored, measured at 264 and 278 nm, with linearity ranges of 2.0-140.0 and 3.0-160.0 µg/mL for azithromycin dihydrate and roxithromycin, respectively. The proposed methods were subjected to detailed validation procedure; moreover they were used for the estimation of the concerned drugs in their different dosage forms. Study of the reactions stoichiometry was carried out; furthermore, a reaction mechanism proposal was presented. Atlanta Publishing House LLC 2017-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1574 10.5155/eurjchem.8.3.203-210.1574 European Journal of Chemistry; Vol. 8 No. 3 (2017): September 2017; 203-210 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1574/pdf_1574