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oai:ojs.www.eurjchem.com:article/1576 2017-09-30T11:59:49Z eurjchem:ART driver

Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality Naz, Mehwish Akhter, Zareen Zaka, Ayesha Mirza, Bushra McKee, Vickie Ullah, Ehsan Bolte, Michael Hyperchromism DNA damaging assay Bifunctional aldehyde Chemotherapeutic agent Pharmacological activities Bifunctional aldehyde-DNA interaction Recent work aimed at evaluating the possibility of enhancing biological activities by synthetically modifying bifunctional aldehyde structures. In this article, two series of bifunctional aldehydes were synthesized, structurally characterized (M-1A, M-1C and M-2A) using single crystal X-ray diffraction analysis. Several pharmacological properties like cytotoxic, antifungal, antibacterial, antioxidant and antitumor activities were also evaluated. In addition, bifunctional aldehyde-DNA interaction assay was examined by UV-Vis spectroscopy which revealed the DNA damaging behaviour of these aldehydes. The results of UV-Vis spectroscopy were supported by DNA damaging assay. The overall results reveal that bifunctional aldehyde moiety could be used as potential drug candidates. Atlanta Publishing House LLC 2017-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain text/plain text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/1576 10.5155/eurjchem.8.3.195-202.1576 European Journal of Chemistry; Vol. 8 No. 3 (2017): September 2017; 195-202 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1576/pdf_1576 https://www.eurjchem.com/index.php/eurjchem/article/view/1576/2596 https://www.eurjchem.com/index.php/eurjchem/article/view/1576/2597 https://www.eurjchem.com/index.php/eurjchem/article/view/1576/2598