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oai:ojs.www.eurjchem.com:article/1599 2017-09-30T11:59:49Z eurjchem:ART driver

Heteroaromatization with 4-phenyldiazenyl-1-naphthol. Part II: Synthesis of some new benzochromens, benzochromenopyrimidines, benzochromenotriazolopyrimidines, benzochromenopyrimidotriazepine and antimicrobial activities Radini, Ibrahim Ali Hamed, Hany Mostafa Kharir, Mohammed Abdo Yahya Elwahab, Ashraf Hassan Fekry Abd Benzochromene Antimicrobial activities Benzochromenopyrimidine 4-Phenenyldiazenyl-1-naphthol Benzochromenotriazolopyrimidine Benzochromenopyrimidotriaziepine Synthesis of several new of benzochromenes (4-7), benzochromenopyrimidines (8 and 9), 14-(4-chlorophenyl)-12-(phenyldiazenyl)-14H-benzo[7,8]chromeno[3,2-e][1, 2, 4]triazolo[1, 5-c]pyrimidines, 4-amino-16-(4-chlorophenyl)-14-(phenyldiazenyl)-16H-benzo[7', 8']chro-meno[2',3':4,5]pyrimido[1,6-b][1,2,4]triazepine-3-carbonitrile (10a-e, 13) and 9-(benz-ylideneamino)-7-(4-chlorophenyl)-5-(phenyldiazenyl)-7, 9-dihydro-8H-benzo[7,8]chromeno [2,3-d]pyrimidin-8-imine (12), form starting from 2-amino-4-(p-chlorophenyl)-6-phenyl-diazenyl-4H-benzochromene-3-carbonitrile (3). The structure of these new compounds was confirmed using IR, 1H NMR and 13C NMR as well as MS spectroscopy. The structure activity relationship studies of the target compounds in agreement with the in vitro essays and confirmed higher potent antimicrobial activity against some of the tested microorganisms. The structure-activity relationship study revealed that the antimicrobial activity of benzochromenopyrimido triazepine nucleus was more beneficial than benzochromeno-triazolopyrimidine nucleus for antimicrobial activity. Atlanta Publishing House LLC 2017-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1599 10.5155/eurjchem.8.3.240-247.1599 European Journal of Chemistry; Vol. 8 No. 3 (2017): September 2017; 240-247 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1599/pdf_1599