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Molecular self-assembly in indole-based benzamide derivative: Crystal structure, Hirshfeld surfaces and antimicrobial activity Gumus, Ilkay Solmaz, Ummuhan Gonca, Serpil Arslan, Hakan Antimicrobial activity Single crystal structure Molecular self-assembly Hirshfeld surface analysis Deformation electron density Indole-based benzamide derivative Two new compounds, 1H-indole-7-amine (1) and N-(1H-indol-7-yl)-2-methylbenzamide (2) were synthesized and structurally characterized by NMR and FT-IR spectroscopic techniques. The molecular structure of compound 2 was further elucidated by single-crystal X-ray diffraction technique. Moreover, the crystal packing of compound 2 is analyzed in terms of non-covalent N-H···O, C-H···π, and parallel displaced π···π interactions. Hirshfeld surface analysis and decomposed fingerprint plots of the compound 2 were performed to visualize the presence of strong hydrogen bond N-H···O and C-H···π stacking interactions. Hirshfeld surface analysis and decomposed fingerprint plots show that the structure of compound 2 is stabilized by H···H, N-H···O, C-H···π and π···π intermolecular interactions and these interactions contribute mostly to molecular self-assembly in the crystal. In addition, compound 2 was evaluated for both their in-vitro antibacterial and antifungal activity. The obtained results have been reported, explained and compared with fluconazole and ampicillin used as reference drugs. Atlanta Publishing House LLC 2017-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/1637 10.5155/eurjchem.8.4.349-357.1637 European Journal of Chemistry; Vol. 8 No. 4 (2017): December 2017; 349-357 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1637/pdf_1637 https://www.eurjchem.com/index.php/eurjchem/article/view/1637/2601 Copyright (c) 2017 Authors