2026-05-08T05:03:18Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1645 2018-03-11T13:45:35Z eurjchem:ART driver

Synthesis and antiproliferative activity of 3-(substituted)-4,5,6,7-tetrahydro-6-(substituted)-1H-pyrazolo[3,4-c]pyridine derivatives Pawar, Chandrakant Pansare, Dattatraya Shinde, Devanand Pd/C Antiproliferative Aurora-A kinases 5 6-Dihydropyrazole Tetrahydropyridine 4 6 7-Tetrahydropyrazole A series of new molecules having 3-(substituted)-4,5,6,7-tetrahydro-6-(substituted)-1H-pyrazolo[3,4-c]pyridine and 3-(substituted)-5,6-dihydro-6-(substituted)-1H-pyrazolo[3,4-c] pyridin-7(4H)-one derivatives were designed and synthesized in large scale (grams range). The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR, Mass spectra; and purity was also checked through LC/MS and HPLC analysis. The antiproliferative activity of the compounds was checked for lung cancer, cervical cancer, breast cancer and prostate cancer on panel of four cell lines. A few compounds (13c, 13g, 15g and 15h) showed promising antiproliferative activity in the range of 5.12-17.12 µM which were further tested for their inhibitory activity against panel of 8 human kinases at 10 µM concentrations. The compounds 13c, 13g, 15g and 15h shows prominent inhibitory activity against Aurora-A, Aurora-B, CDK5/P25 and mTOR kinases. Atlanta Publishing House LLC 2017-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1645 10.5155/eurjchem.8.4.400-409.1645 European Journal of Chemistry; Vol. 8 No. 4 (2017): December 2017; 400-409 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1645/pdf_1645