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oai:ojs.www.eurjchem.com:article/1659 2018-03-11T13:45:35Z eurjchem:ART driver

Reactions of 5-(4-methoxy-3-methylphenyl)-2(3H)-furanone with some electrophilic and nucleophilic reagents Soliman, Mohamed Helmy Abd El-hamied El-Sakka, Sahar Said Ahmed Isothiazolone Pyridazinone 2(3H)-Furanone 4-Oxobutanamide o-Phenylenediamine Condensation reaction 5-(4-Methoxy-3-methylphenyl)-2(3H)-furanone was prepared and reacted with some nucleophilic and electrophilic reagents. The condensation of furanone with aromatic aldehydes or phthalic anhydride yielded the corresponding 3-arylidenefuranone derivatives and phthalide, respectively. While the treatment of furanone with amines in refluxing ethanol led to the formation of amides. The reaction of the amides with thionyl chloride afforded the corresponding isothiazolones. The benzimidazole derivative was prepared via the reaction of the 2(3H)-furanone with o-phenylenediamine in boiling ethanol. However, hydrazine hydrate affected ring opening of furanone to give the corresponding acid hydrazide, which underwent in situ cyclization into the corresponding pyridazinone. The base catalyzed ethanolysis of furanone afforded the corresponding ethyl ester. Atlanta Publishing House LLC 2017-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1659 10.5155/eurjchem.8.4.417-421.1659 European Journal of Chemistry; Vol. 8 No. 4 (2017): December 2017; 417-421 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1659/pdf_1659