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oai:ojs.www.eurjchem.com:article/168 2011-09-30T03:44:50Z eurjchem:ART driver

Synthesis of novel pyrimidine and fused pyrimidine derivatives Mahmoud, Mahmoud Refaee El-Ziaty, Ahmed Kamel Ismail, Mahmoud Fawzy Shiba, Sayed Ahmed s-Benzylthiuronium chloride Activated nitriles Pyrimidines Triazolopyrimidine derivatives Antiviral activity Cytotoxicity 4-Amino-2-(benzylthio)-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile (1) was prepared by treatment of s-benzylthiuronium chloride with 2-(4-methoxybenzylidene)malononitrile in ethanolic sodium hydroxide with hydrazine hydrate to afford the hydrazino derivative 2, which was allowed to react with different electrophilic reagents to give the pyrimidine derivatives 3-12. The proclivity of (E)-2-cyano-3-(4-nitrophenyl)acrylamide (13) towards carbon and nitrogen nucleophiles was also investigated. IR, 1H NMR and mass spectra for all the synthesized compounds were discussed. All derived compounds were investigated for anti avian influenza (H5N1) virus activity and compared with zanamivir as control drug. All the synthesized compounds didn’t possess any antiviral activity. Atlanta Publishing House LLC 2011-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/168 10.5155/eurjchem.2.3.347-355.168 European Journal of Chemistry; Vol. 2 No. 3 (2011): September 2011; 347-355 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/168/PDF