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Complexation equilibria of ambroxol hydrochloride in solution by potentiometric and conductometric methods Naggar, Ahmed Hosny Al-Saidi, Hammed Mohammed Farghaly, Othman Abd El-Moaty Hassan, Taher Mohammed Bortata, Salma Zaidan Mohamed Potentiometry Conductometry Metal complexes Stability constants Ambroxol hydrochloride Species distribution diagrams The formation constants of Li(I), Mg(II), Sr(II), Ca(II), Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Ba(II), Pb(II), Al(III), Cr(III), Fe(III) and Th(IV) ions with ambroxol hydrochloride (AMB) were calculated using the half-n value. In presence of 0.1 M NaNO3, metal ions such as Zn(II), Cd(II), Ni(II), Cr(III), Li(I), Mg(II) and Al(III) forms three types of metal-ligand complexes (1:1, 1:2 and/or 1:3), while Sr(II) and Co(II) tend to form two types of metal complexes 1:1 and 1:2 (M:L). For ligand protonation constants, two logarithmic association constant values were calculated by the half-n method and are 10.7 and 7.6, respectively. The effect of ionic strength on stability constant of AMP, with different metal ions viz. Fe(III), Th(IV), Al(III), Cr(III) and Cu(II) was studied. Based on relationship between the ionic strength studied values and the 1st stability constants (Log K1H), we can conclude that the stability constants of the formed metal-ligand complex (1:1) were decreased as the ionic strength increased. The stoichiometry of the formed complexes in solution were determined by conductometric method and it is found to be of 1:1, 1:2 and/or 1:3 (M:L) complex species is formed in alkaline media. Also, study the species distribution diagrams of AMP for the calculated mole fraction αML and αML2 were discussed. Atlanta Publishing House LLC 2018-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1682 10.5155/eurjchem.9.1.49-56.1682 European Journal of Chemistry; Vol. 9 No. 1 (2018): March 2018; 49-56 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1682/pdf_1682 Copyright (c) 2018 Authors