2026-05-04T19:37:15Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/171 2011-12-31T08:09:40Z eurjchem:ART driver

Novel 4(3H)-quinazolinones containing biologically active thiazole, pyridinone and chromene of expected antitumor and antifungal activities El-Bayouki, Khairy Abdel Hameed Mohsen Basyouni, Wahid Mohamed Mohamed, Yahia Abdel Fatah Aly, Mohsen Mohamed Abbas, Samir Youssef 4(3H)-Quinazolinone Thiazole Pyridinone Chromene Antitumor Antifungal activity Novel 4(3H)-quinazolinone derivatives with biologically active moieties were synthesized. Reactions of 2-cyano-N-(6-iodo-2-methyl-4-oxoquinazolin-3(4H)-yl) acetamide with carbon disulfide, isothiocyanates followed by cycloalkylation afforded acrylamide, 1,3-dithiazole, 1,3-dithiane, thiazole and pyrazole derivatives. The 2-pyridone derivatives were obtained via reaction of cyanoacetamide with some acetylacetone or arylidenes. Cyclocondensation reaction of cyanoacetamide with o-hydroxy aldehydes furnished chromene derivatives. Screening for some selected compounds was carried for their potential antitumor and antifungal activities. 2-Cyano-N-(6-iodo-2-methyl-4-oxoquinazolin-3(4H)-yl)-2-(4-methyl-3-phenyl-thiazol-2(3H)ylidene)-acetamide with 3-side chain incorporated with substituted thiazole moiety was found to be of high to moderate activity towards cells. Also, the latter product showed high activity against Aspergillus ochraceus Wilhelm with inhibition zone (18 mm) compared with (20 mm) Nystatin inhibition zone. Atlanta Publishing House LLC 2011-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/171 10.5155/eurjchem.2.4.455-462.171 European Journal of Chemistry; Vol. 2 No. 4 (2011): December 2011; 455-462 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/171/PDF