2026-05-05T03:45:57Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1748 2018-12-31T07:23:25Z eurjchem:ART driver

Quinazolin derivatives as emerging alpha-glucosidase inhibitors Ankireddy, Ashok Reddy Gundla, Rambabu Balaraju, Tuniki Banothu, Venkanna Gundla, Krishna Prasad Addepally, Uma Chimakurthy, Jithendra Diabetes Acarbose Inhibitors Inflammation Alpha-glucosidase Quninazoline derivatives A series of C-7 substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine have been synthesized and biochemical assay was examined against α-glucosidase function inhibition activity. A structure activity and structure property relationship study was experimented to surface the new hit compound. This study led to the identification of C-7substituted quinazolines with minimum inhibitory concentrations (MICs) in the preffered micromolar range in addition with interesting physicochemical properties. Biological evaluation yielded eight analogs which rose with significant α-glucosidase inhibition potency (IC50 values < 2 μM, where reference compound (Acarbose) potency value is IC50 = 0.586 uM) and could be promising candidates for further lead optimization. Atlanta Publishing House LLC 2018-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1748 10.5155/eurjchem.9.4.322-330.1748 European Journal of Chemistry; Vol. 9 No. 4 (2018): December 2018; 322-330 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1748/pdf_1748 Copyright (c) 2018 Authors