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oai:ojs.www.eurjchem.com:article/1852 2020-03-31T03:28:36Z eurjchem:ART driver

Indirect detection of 5-hydroxytryptamine and tyramine by using tris(2,2’-bipyridyl)ruthenium-graphene modified electrode coupled with capillary electrophoresis Zhao, Zi Wei Li, Fan Lin Su, Ming Graphene Tyramine 5-Hydroxytryptamine Electrochemical sensor Capillary electrophoresis Electrochemiluminescence A highly sensitive and stable solid-state electrochemiluminescence (ECL) sensor was developed based on tris(2,2’-bipyridyl)ruthenium(II) (Ru(bpy)32+) integrating with 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) functionalized graphene. Ru(bpy)32+ is incorporated with the ABTS functionalized graphene based on not only the π-π stacking but also electrostatic interactions. Coupled with capillary electrophoresis (CE), this ECL sensor was used to detect tyramine and 5-hydroxytryptamine (5-HT) based on their quenching effects for the Ru(bpy)32+/tripropylamine (TPA) system. The quenching mechanism was illustrated and the conditions for CE separation and ECL detection were optimized. Based on an S/N = 3, the limit of detection (LOD) for tyramine and 5-HT were 0.1 μM and 0.02 μM, respectively. The applicability of the proposed method was further illustrated in the determination of tyramine and 5-HT in human plasma samples from small intestine carcinoid patients. Atlanta Publishing House LLC 2019-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1852 10.5155/eurjchem.10.4.336-344.1852 European Journal of Chemistry; Vol. 10 No. 4 (2019): December 2019; 336-344 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1852/pdf_1852 https://www.eurjchem.com/index.php/eurjchem/article/view/1852/2642 Copyright (c) 2019 Authors