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oai:ojs.www.eurjchem.com:article/1858 2019-06-30T04:04:09Z eurjchem:ART driver

Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone Shaikh, Irfan Vohra, Aliasgar Devkar, Ranjitsinh Jadeja, Rajendrasinh ONS donors Cytotoxicity Zn(II) complex Thio-Schiff base Single crystal structure Acyl pyrazolone derivatives Novel acyl pyrazolone and thio-Schiff base of acyl pyrazolone ligand HL (2-((4-chlorophenyl)(1-(3-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methylene) hydrazine-1-carbothioamide) has been synthesised and characterized by FT-IR and 1H NMR techniques. This unusual coordinated complex [Zn(L)(CH3C00)(H2O)]CH3CH2OH has been synthesized and characterized by FT-IR, thermogravimetric analysis (TGA), UV-Vis spectroscopy and single crystal X-ray diffraction. 1H NMR confirms the structure of the thio-Schiff base used in the study. The structural data reveal that mononuclear Zn(II)complex has distorted square pyramidal geometry. S-S interaction, Inter molecular and intra molecular H-Bond found in crystal packing of the complex. The complex has been screened for MTT assay against A549 cell lines. The Zn(II) complex is cytotoxic against the screened cell line at low concentration.  Atlanta Publishing House LLC 2019-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/1858 10.5155/eurjchem.10.2.131-138.1858 European Journal of Chemistry; Vol. 10 No. 2 (2019): June 2019; 131-138 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1858/pdf_1858 https://www.eurjchem.com/index.php/eurjchem/article/view/1858/2631 Copyright (c) 2019 Authors