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oai:ojs.www.eurjchem.com:article/193 2011-12-31T08:09:40Z eurjchem:ART driver

Synthesis and reactions of (Z)-2-imino-5-(3,4,5-trimethoxy benzylidene)thiazolidin-4(H)one Mahmoud, Mahmoud Refaee Madkour, Hassan Mohamed Fawzy El-Bordany, Eman Abd El-Fattah Soliman, El-Sayed Ahmed Iminothiazolidinone derivatives Grignard reagents Imidazolidinone derivative 2-Thiazolidin-4-one Nitrogen nucleophiles Activated nitriles 5-Arylmethylene-2-imino-4-oxo-2-thiazolidine 3 was obtained as the sole product from the reaction of α-cyano-3,4,5-trimethoxy cinnamonitrile and/or ethyl-α-cyano-3,4,5-trimethoxy cinnamate (1a,b) with 2-imino-4-oxo-2-thiazolidine 2. The reaction of 3 with benzyl amine gave the imidazolidin-4(H)one derivative 4 while with hydrazine hydrate afforded the dimeric product 5. Also, reaction of thiazolidinone derivative 3 with piperidine gave thiazol-4(5H)one derivative 6 which on treatment with Grignard reagent and active methylene compounds afforded thiazolidin-4-one derivatives 7-9, respectively. Compound 6 was converted to the potassium salt 10 which treated with acetic acid, ethyl chloroacetate and furoyl chloride to give the compounds 11-13, respectively. The structures of all new compounds were evidenced by microanalytical data and spectral data. Atlanta Publishing House LLC 2011-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/193 10.5155/eurjchem.2.4.475-479.193 European Journal of Chemistry; Vol. 2 No. 4 (2011): December 2011; 475-479 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/193/PDF