2026-05-09T14:47:17Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1956 2020-06-30T03:45:36Z eurjchem:ART driver

Spectrum subtraction method for simultaneous determination of acetaminophen and caffeine in panadol extra dosage forms Sebaiy, Mahmoud Mohammed Mattar, Amr Abd El-Hakeem Caffeine ICH guidelines Acetaminophen Spectrophotometric Spectrum subtraction Statistical comparison A simple, specific, accurate and precise spectrophotometric method was established for simultaneous determination of acetaminophen and caffeine in pure form and in their pharmaceutical formulation commercially known as Panadol Extra®. Spectrum subtraction has been used in simultaneous determination of both drugs without prior separation. Spectrum subtraction method parameters were validated according to ICH guidelines in which accuracy, precision, repeatability and robustness were found in accepted limits (98-102%). The linearity range was 7.5-45 µg/mL for caffeine and 4-22 µg/mL for acetaminophen with correlation coefficients ≥0.9990 for both drugs. Advantages and disadvantages of spectrum subtraction were discussed and statistical comparison between the proposed method and the reference one was performed. Atlanta Publishing House LLC 2020-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1956 10.5155/eurjchem.11.1.80-83.1956 European Journal of Chemistry; Vol. 11 No. 1 (2020): March 2020; 80-83 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1956/pdf_1956 Copyright (c) 2020 Authors