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Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors Bakhotmah, Dina Alotaibi, Fatimah Synthesis 1 2 4-Triazine Pyrimido-[1 2-b]-[1 4]triazine [1 3 5]-Triazino[1 CDK2 enzymatic inhibitors evaluation Fluorinated fused heterocyclic systems New fluorine-substituted polyfunctional pyrimido-[1,2-b]-[1,2,4]triazines and [1,3,5]-triazino[1,2-b]-[1,2,4]triazines were synthesized via the reaction between 3-amino-6-(2-aminophenyl)-1,2,4-triazin-5(2H)-one with polyfunctional oxygen/sulfur/nitrogen reagents under different conditions. Structures of the target compounds were deduced by elemental analysis and spectral measurements (IR, 1H/13C NMR, and mass spectra). According to the obtained inhibitor assay results, the inhibition activity of the new fluorine-substituted 1,2,4-triazines toward CDK2 decreased in the order of compounds 3 > 8 > 9 > 6 > 13 > 15. Atlanta Publishing House LLC 2020-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1988 10.5155/eurjchem.11.3.198-205.1988 European Journal of Chemistry; Vol. 11 No. 3 (2020): September 2020; 198-205 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1988/pdf_1988 Copyright (c) 2020 Authors