2026-05-09T13:44:31Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/20 2011-04-06T05:44:40Z eurjchem:ART driver

Synthesis and bioactivity of phosphorylated derivatives of stavudine Rao, Alahari Janardhan Rao, Valasani Koteswara Rao, Pasupuleti Visweswara Raju, Chamarthi Naga Ghosh, Sunil Kumar Phosphorylated derivatives of stavudine Gram-positive bacteria Gram-negative bacteria Antibacterial activity Antioxidant activity Novel phosphorylated derivatives of stavudine were synthesized by the reaction of bis(2-chloroethyl)phosphoramidic dichloride/4-nitrophenyl phosphorodichloridate with various cyclic amines and amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the corresponding monochloride intermediates 2a-l. Further reaction of the intermediates 2a-l with stavudine in tetrahydrofuran and pyridine in the presence of triethylamine formed the title compounds 4a-l. Their structures were characterized by IR,   1H-, 13C-, 31P-NMR and mass spectral data analyses. They exhibited good antibacterial and antioxidant activities. Their bioactivity was greatly influenced by the different groups present at the phosphorus. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/20 10.5155/eurjchem.1.4.297-301.20 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 297-301 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/20/PDF