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oai:ojs.www.eurjchem.com:article/201 2011-04-06T06:10:52Z eurjchem:SC driver

Synthesis of 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one from Tessmannia densiflora Saeed, Aamer Isocoumarin Tessmannia densiflora 3 5-Dimethoxyhomophthalic acid Antimalarial 5-Dimethoxyhomophthalic anhydride Mechanism The synthesis of 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one (1) isolated from the stem and root bark extracts of Tessmannia densiflora has been described. The reaction of 3,5-dimethoxyhomophthalic anhydride (2) with hexanoyl chloride in the presence of 1,1,3,3-tetramethylguanidine and triethylamine afforded 6,8-dimethoxy-3-pentylisocoumarin (3). Regioselective demethylation of the latter using anhydrous aluminum chloride furnished the title isocoumarin (1). Atlanta Publishing House LLC 2011-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/201 10.5155/eurjchem.2.1.117-119.201 European Journal of Chemistry; Vol. 2 No. 1 (2011): March 2011; 117-119 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/201/PDF