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oai:ojs.www.eurjchem.com:article/2033 2021-03-31T07:18:54Z eurjchem:ART driver

Efficient synthesis of diversely substituted pyrazolo[1,5-a]pyrimidine derivatives promoted by ultrasound irradiation in water and their antibacterial activities Das, Susma Khanikar, Shilpika Kaping, Shunan Roy, Jayanti Datta Sen, Arnab Helissey, Philippe Vishwakarma, Jai Narain Enaminone Single crystal 3-Aminopyrazole Ultrasonic irradiation X-ray crystallography Antibacterial properties A green synthetic route leading to the discovery of a series of diversely substituted pyrazolo[1,5-a]pyrimidines, having CO2Et group embedded at position-2 has been unraveled in this article. A series of formylated active proton compounds that were chosen to react with a carboxylate substituted-3-aminopyrazole under ultrasonic irradiation in the presence of a mild acid as a catalyst and aqueous ethanol medium afforded the desired products. The molecular structures of all these synthesized compounds were established by their spectral and analytical data. A model molecule 3d, subjected to single-crystal X-ray crystallography analysis further confirms their molecular structure. The crystal crystallized to a monoclinic cell with P21/c space group, a = 7.468 (5) Å, b = 27.908 (17) Å, c = 7.232 (4) Å, β = 104.291 (7)o, V =1460.7(15) Å3, Z = 4, μ(MoKα) = 0.096 mm-1, Dcalc = 1.352 Mg/m3 16667 measured reflection (5.63 ≤ 2Θ ≤ 57.57°), 3720 unique (Rint = 0.0965, Rsigma = 0.0945) which were used in all calculations. The final R1 was 0.0750 (I > 2σ(I)) and wR2 was 0.2226 (all data). These compounds were further explored for their antibacterial potential, and a few of them have exhibited encouraging results. Atlanta Publishing House LLC 2020-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2033 10.5155/eurjchem.11.4.304-313.2033 European Journal of Chemistry; Vol. 11 No. 4 (2020): December 2020; 304-313 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2033/pdf_2033 Copyright (c) 2020 Authors