2026-05-30T13:05:10Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/206 2011-06-30T10:44:15Z eurjchem:ART driver

Synthesis and anti-tubercular activity of novel pyrazol-5(H)-one derivatives Raval, Jignesh Priyakant Shah, Arpita Bharatbhai Patel, Nilesh Hasmukhbhai Patel, Hemul Venubhai Patel, Pradip Shantilal Bhatt, Kashyap Kanaiyalal Desai, Kishor Ratilal Isonicotinohydrazide Pyrazol-5(H)-ones Anti-tubercular activity Anti-mycobacterial activity Mycobacterium tuberculosis M. tuberculosis H37Rv In the present investigation, a series of 1-isonicotinoyl-3-methyl-4-(2-(substituted-phenyl)hydrazono)-1H-pyrazol-5(H)-ones were synthesized by the reaction between isonicotinohydrazide with substituted ethylacetoacetate derivatives using acetic acid as solvent which yielded substituted pyrazol-5(H)-one derivatives. Newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the synthesized compounds, 4-(2-(2,6-dichlorophenyl)hydrazono)-1-isonicotinoyl-3-methyl-1H-pyrazol-5(4H)-one and 4-(2-(1-isonicotinoyl-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl) benzene-sulfonamide were found to be more active agent against M. tuberculosis H37Rv with minimum inhibitory concentration of 0.0034, 0.0032 µM at actual MIC 1.66 and 1.64 µg/mL, respectively. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/206 10.5155/eurjchem.2.2.238-242.206 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 238-242 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/206/PDF