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The synthesis and crystallographic characterization of 4-methylbenzenesulfonamide derivatives Stenfors, Brock Anton Ngassa, Felix Nyuangem Tosylation Sulfa drugs Methodology Sulfonamides Crystal structures Packing polymorph The sulfonamide moiety is present among a variety of biologically significant compounds. A facile synthesis is necessary to produce a variety of sulfonamides with the potential to improve human health. Herein, we report a facile methodology for the synthesis of 4-methylbenzenesulfonamides, amenable to a broad range of nitrogen nucleophiles. Implementing a semi-miscible biphasic solvent system resulted in higher yields, decreased reaction times, and a simplified workup over preliminary methods. Additionally, the crystal structures of five novel sulfonamide compounds and two polymorphs, have been determined by X-ray diffraction. Results obtained through spectroscopic characterization support the successful formation of the desired 4-methylbenzenesulfonamides. Atlanta Publishing House LLC 2021-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain text/plain text/plain text/plain text/plain text/plain text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/2064 10.5155/eurjchem.12.2.109-116.2064 European Journal of Chemistry; Vol. 12 No. 2 (2021): June 2021; 109-116 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2064/pdf_2064 https://www.eurjchem.com/index.php/eurjchem/article/view/2064/2655 https://www.eurjchem.com/index.php/eurjchem/article/view/2064/2692 https://www.eurjchem.com/index.php/eurjchem/article/view/2064/2693 https://www.eurjchem.com/index.php/eurjchem/article/view/2064/2696 https://www.eurjchem.com/index.php/eurjchem/article/view/2064/2698 https://www.eurjchem.com/index.php/eurjchem/article/view/2064/2699 https://www.eurjchem.com/index.php/eurjchem/article/view/2064/2703 Copyright (c) 2021 Authors