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Bivalent metal complexes of a novel modified nicotinic acid hydrazide drug: Synthesis, characterization, and anti-tubercular studies Mikwa, Cyprian Chunkang Toh-Boyo, Gwendoline Mochia Njong, Romanus Nyako Ndoye, Bridget Ndosiri Ndamyabera, Christophe Adrien Katsuumi, Natsuki Mitani, Yuta Nfor, Emmanuel Ngwang Akitsu, Takashiro Schiff base Complexes Hydrazones Crystal structure Anti-tubercular activity Nicotinic acid hydrazide Iron(II) and manganese(II) complexes of N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (LH) have been synthesized and characterized by elemental analysis, IR, and 1H NMR spectroscopy. The crystal structure of the ligand has been determined by single crystal X-ray diffraction and electronic spectroscopic techniques. Crystal data for LH, C13H12N4O: Orthorhombic, space group Pbcn (no. 60), a = 18.0824(3) Å, b = 7.86555(14) Å, c = 16.1614(3) Å, V = 2298.60(7) Å3, Z = 8, T = 103 K, μ(Mo Kα) = 0.093 mm-1, Dcalc = 1.388 g/cm3, 36729 reflections measured (5.042° ≤ 2Θ ≤ 54.966°), 2633 unique (Rint = 0.0224, Rsigma = 0.0124) which were used in all calculations. The final R1 was 0.0383 (F2>2σ(F2)) and wR2 was 0.0988 (all data). The ligand was found to chelate to the metal ions through the azomethine nitrogen and amide oxygen atoms in a bidentate manner. The anti-tubercular activity of the ligand, its iron (II) and manganese (II) complexes were studied against Mycobacterium tuberculosis (ATTC 27294). The results revealed higher activity of the iron (II) complex with MIC value of 8.00±0.83 µM and a moderate activity of the manganese (II) complex having MIC value of 14.20±1.40 µM, compared to the reference drugs having MIC values of 9.41±0.92, 10.74±1.02, 25.34±2.6 µM and parent ligand with MIC value of 17.60±1.80 µM. Atlanta Publishing House LLC 2022-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/2183 10.5155/eurjchem.13.1.63-68.2183 European Journal of Chemistry; Vol. 13 No. 1 (2022): March 2022; 63-68 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2183/pdf_2183 https://www.eurjchem.com/index.php/eurjchem/article/view/2183/2727 Copyright (c) 2022 Authors