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Synthesis, reactions, and applications of chalcones: A review Morsy, Nesrin Mahmoud Hassan, Ashraf Sayed Synthesis Reactions Chalcones Applications Chemical method Biological activity Considering the essential biological and medicinal properties of chalcones, the synthesis of these compounds has attracted the interest of medicinal and organic chemists. This review aims to describe the different strategies developed so far for the synthesis of chalcones and their applications. After a brief introduction of the chalcones and their biological activities, different synthetic approaches such as chemical and other methods are described and organized on the basis of the catalysts and the other reagents employed in the syntheses. Some of the reactions have been applied successfully to the synthesis of biologically important compounds. Moreover, the biological and pharmacological activities of chalcones have been shown. Atlanta Publishing House LLC 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2245 10.5155/eurjchem.13.2.241-252.2245 European Journal of Chemistry; Vol. 13 No. 2 (2022): June 2022; 241-252 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2245/pdf_2245 Copyright (c) 2022 Authors