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Synthesis, physicochemical characterisation and DNA binding study of a novel azo Schiff base Ni(II) complex Singha, Uttam Kumar Pradhan, Sudarshan Mishra, Dipu Kumar Gurung, Pritika Chettri, Anmol Sinha, Biswajit CT-DNA Ni(II) complex Azo Schiff base DNA binding study Molecular docking DNA cleavage study The azo Schiff base ligand was synthesised, along with its Ni(II) complex, by diazotisation of salicylaldehyde with 4-nitroaniline in accordance with the accepted literature approach. Using a variety of spectroscopic techniques, the resulting complex is analysed both quantitatively and qualitatively (Elemental analysis, FT-IR spectroscopy, UV-VIS spectroscopy, 1H NMR, etc.). Spectral measurements of the complex revealed a mole ratio of 1:1. The non-electrolytic nature of the complex is confirmed by molar conductance investigation. The unique azo compound had a tetrahedral shape as a result of the tetra coordination of two phenolic oxygen and two imine nitrogen. The ability of the metal complexes to bind DNA was examined using absorption spectroscopy, fluorescence spectroscopy, viscosity tests, and thermal denaturation methods. Experimental research suggests that complexes bind to DNA through intercalation. Atlanta Publishing House LLC 2023-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2375 10.5155/eurjchem.14.2.280-286.2375 European Journal of Chemistry; Vol. 14 No. 2 (2023): June 2023; 280-286 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2375/pdf_2375 Copyright (c) 2023 Authors