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Newer chalcone scaffolds with reactive functional groups: Process, spectral and single crystal XRD studies Borane, Niteen Deshmukh, Amar Ghanshyam Oza, Nidhi Harnesh Boddula, Rajamouli Patel, Paresh Narayan Nitrile Chalcone Pyrrolidine Heterocycle Single-crystal XRD 4-Formylbenzonitrile Chalcones are versatile scaffolds for the synthesis of various heterocyclic systems with commercial utility. This work describes the synthesis of five novel chalcone derivatives. Syntheses were performed by a simple one-pot, straightforward Claisen-Schmidt condensation catalyzed with pyrrolidine and KOH. The chalcones were prepared by condensation of 4-formylbenzonitrile with different aromatic ketones at room temperature. The structures of all compounds have been investigated by FT-IR, NMR, and HR-MS spectroscopy. In addition, one chalcone structure was characterized by single-crystal XRD study. Crystal data for C21H15NO2 (Ch2): monoclinic, space group P21/c (no. 14), a = 6.5694(3) Å, b = 33.2697(15) Å, c = 7.4516(4) Å, β = 97.563(2)°, V = 1614.47(14) Å3, Z = 4, T = 293(2) K, μ(MoKα) = 0.083 mm-1, Dcalc = 1.289 g/cm3, 16000 reflections measured (4.898° ≤ 2Θ ≤ 49.99°), 2822 unique (Rint = 0.0249, Rsigma = 0.0196) which were used in all calculations. The final R1 was 0.0484 (I > 2σ(I)) and wR2 was 0.1257 (all data). The absorption maxima of all novel products were evaluated by UV-visible spectroscopy. These well-established structures of all newly prepared chalcone scaffolds with reactive functional groups (i.e. nitrile and 2-propenone) can be exploited as a crucial intermediate in the synthesis of new heterocyclic scaffolds with fluorescence and other applications. Atlanta Publishing House LLC 2023-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/2405 10.5155/eurjchem.14.2.297-302.2405 European Journal of Chemistry; Vol. 14 No. 2 (2023): June 2023; 297-302 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2405/pdf_2405 https://www.eurjchem.com/index.php/eurjchem/article/view/2405/2747 Copyright (c) 2023 Authors