2026-04-10T14:30:28Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/2457 2023-12-31T06:19:35Z eurjchem:ART driver

Magnetically recoverable nanocatalyst for the synthesis of pyranopyrazoles: CoFe2O4@SiO2-HClO4 Thakare, Nikita Vinod Aswar, Anand Shankar Salunkhe, Nilesh Govindrao Solvent-free Pyranopyrazoles Microbial activity Microwave-assisted Multicomponent reaction Magnetically recoverable catalyst The multiheterocyclic ring system shows valuable pharmaceutical and biological activities. In the present study, a microwave-assisted three-component reaction between aryl aldehyde, malononitrile, and 5-methyl-2,4-dihydro-3H-pyrazole-3-one led to the synthesis of pyrano[2,3-c]pyrazoles has been described. The reaction was carried out under solvent-free conditions in the presence of a new magnetically recoverable nanocatalyst (CoFe2O4@SiO2-HClO4). The reported protocol offers several advantages such as being environmentally benign, being rapid, inexpensive, having high atom and step economy, and being facile. The simple method of catalyst preparation, easy magnetic recovery, and reusability of the catalyst for four runs are notable features of the nanocatalyst. Antibacterial activity of all synthesized compounds was tested against Escherichia coli and Staphylococcus aureus. All synthesized compounds showed promising biological activity and may be used as a potential antibacterial candidate in biological science. Atlanta Publishing House LLC 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2457 10.5155/eurjchem.14.3.385-392.2457 European Journal of Chemistry; Vol. 14 No. 3 (2023): September 2023; 385-392 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2457/pdf_2457 Copyright (c) 2023 Authors