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oai:ojs.www.eurjchem.com:article/2468 2023-12-31T06:19:31Z eurjchem:ART driver

Design, synthesis, spectral analysis, and biological evaluation of Schiff bases with a 1,3,4-thiadiazole moiety as an effective inhibitor against bacterial and fungal strains Malak, Sajid Ajit Rajput, Jamatsing Dabarsing Sharif, Mustakim Catalysis Schiff bases Thiadiazole Acetophenone Antifungal activity Antibacterial activity Many distinct natural and pharmaceutical items include the well-known heterocyclic nucleus 1,3,4-thiadiazole. Ten Schiff bases of 1,3,4-thiadiazole derivatives have been synthesized using equimolar amounts of 5-styryl-1,3,4-thiadiazol-2-amine and substituted acetophenones in the catalytic amount of ethanol. The synthesized derivatives of Schiff's bases were characterized by FT-IR, 1H NMR, 13C NMR, and mass spectroscopy. The 1,3,4-thiadiazole Schiff’s bases (RM-1 to RM-10) were tested for their in vitro antimicrobial activity against Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus using the disc diffusion method. The 1,3,4-thiadiazole Schiff bases showed strong antibacterial activity against bacterial and fungal species, however, their activity was noticeably less effective than that of the evaluated conventional antibiotics. Atlanta Publishing House LLC 2023-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2468 10.5155/eurjchem.14.4.466-472.2468 European Journal of Chemistry; Vol. 14 No. 4 (2023): December 2023; 466-472 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2468/pdf_2468 Copyright (c) 2023 Authors