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pH and time effectiveness on azithromycin drug: A spectrophotometric approach Saeed, Adel Ahmed Al-Salimi, Mokhtar Salim Muthanna, Amani Khalid Saleh, Maysa Thabet Ahmed, Ahmed Hassan Qasam, Fadhel Mahmoud Alwan, Hadeel Adnan Alturky, Ibrahim Mukhtar Hamood, Musab Muhammed Reduction Drug stability Acidity effect Azithromycin Spectrophotometry Potassium permanganate The present study describes a straightforward method to assess the quality control and diagnostic characteristics of three different brands of film-coated azithromycin tablets. The method is based on the reduction of potassium permanganate in a slightly alkaline solution using azithromycin. The effects of acidity and time were investigated to evaluate the reliability of the method. A spectroscopic technique was used to determine the concentration of azithromycin in a sample by measuring the decrease in potassium permanganate absorbance at a specific wavelength of 547 nm. Azithromycin causes decolorization of potassium permanganate with reduction. The method allowed the determination of azithromycin concentrations ranging from 3-15 μg/mL in the final solution. The usual components present in the azithromycin tablets were observed not to interfere with the method. The results obtained for the determination of azithromycin in tablets were in good agreement with the allowed limit. Atlanta Publishing House LLC 2024-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2522 10.5155/eurjchem.15.2.120-127.2522 European Journal of Chemistry; Vol. 15 No. 2 (2024): June 2024; 120-127 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2522/2787 Copyright (c) 2024 Adel Ahmed Saeed, Mokhtar Salim Al-Salimi, Amani Khalid Muthanna, Maysa Thabet Saleh, Ahmed Hassan Ahmed, Fadhel Mahmoud Qasam, Hadeel Adnan Alwan, Ibrahim Mukhtar Alturky, Musab Muhammed Hamood https://creativecommons.org/licenses/by-nc/4.0