2026-05-09T13:51:24Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/2557 2024-09-30T08:57:08Z eurjchem:REW driver

Sulfonamides and sulfonate esters: Synthetic routes, proposed mechanisms, and crystallographic characterizations Stenfors, Brock Anton Ngassa, Felix Nyuangem Sulfonates Sulfonylation Sulfonamides Sulfonate esters Crystal structures X-ray diffraction data The sulfonamide and sulfonate moieties are key structural features in many pharmaceuticals, agrochemicals, and materials and have proven useful as synthetic precursors. In this review, synthetic routes for sulfonamides and sulfonate esters were examined to gain insight into the mechanism behind the sulfonylation of amines and alcohols, which remains largely unknown and highly dependent on the reaction conditions used. Furthermore, the review delves into crystallographic characterizations of previously reported sulfonamide and sulfonate ester compounds, unraveling trends associated with crucial steric and electronic factors that influence their crystallization. This exploration not only enhances our understanding of the structural nuances of these compounds, but also paves the way for informed design strategies in synthetic and medicinal chemistry. In essence, this review endeavors to provide a holistic perspective on sulfonamides and sulfonate esters, bridging the realms of synthesis, mechanism elucidation, and structural characterization. Atlanta Publishing House LLC 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2557 10.5155/eurjchem.15.3.282-290.2557 European Journal of Chemistry; Vol. 15 No. 3 (2024): September 2024; 282-290 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2557/2846 Copyright (c) 2024 Brock Anton Stenfors, Felix Nyuangem Ngassa https://creativecommons.org/licenses/by-nc/4.0