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oai:ojs.www.eurjchem.com:article/257 2011-06-30T10:44:15Z eurjchem:ART driver

Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents Faidallah, Hassan Mostafa Khan, Khalid Ali Asiri, Abdullah Mohammad 2H-pyran-2-one hydrazones 1-Amino-2H-pyridin-2-ones Benzenesulfonylurea derivatives Thiourea derivatives Antimicrobial activity Antimycobacterial activity Arylhydrazines reacted with dehydroacetic acid (1) to give the corresponding 2H-pyran-2-one hydrazones (2), which on treatment with hydrazine hydrate afforded the corresponding 1-amino-2H-pyridin-2-ones (3). Reaction of 3 with nitrous acid, aromatic aldehyde and substituted benzenesulfonyl chlorides yielded the corresponding 2H-pyridine-2-one derivatives. A series of urea and thiourea derivatives were also prepared. Some of these compounds have shown significant antibacterial and mild to moderate antimycobacterial and antifungal activities. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/257 10.5155/eurjchem.2.2.243-250.257 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 243-250 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/257/PDF