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Synthesis, characterization, crystal structure and antioxidant activity of N-(3-chloropropionyl)-N'-(4-methoxyphenyl)thiourea Abosadiya, Hamza Milad Ahmed Synthesis DPPH method Hydrogen bond Thiourea derivative Antioxidant activity Single-crystal structure In the present work, a new carbonoyl thiourea derivative, N-(3-chloropropionyl)-N'-(4-methoxyphenyl)thiourea, was synthesized by the reaction of 3-chloropropionyl isothiocyanate with 4-methoxyaniline in acetone solution. The newly synthesized compound was characterized by FT-IR, 1H NMR, and 13C NMR spectroscopic techniques. X-ray crystallographic studies indicate that the compound crystallized in the triclinic crystal system with space group P-1 and unit cell dimension are a = 10.2262(6) Å, b = 11.5007(7) Å, c = 12.6116(8) Å, α = 72.253(2)°, β = 66.348(2)°, γ = 88.099(2)°, Z = 4 and V = 1287.22 (14) Å3. Strong intramolecular O-H···N hydrogen bonds are present that form a six-member pseudo-ring S(6). In the crystal structure, the molecules are linked by N-H···O, N-H···S, and C-H···O intermolecular hydrogen bonding interactions formed infinite one-dimensional chains with an R22(8) and R22(12) rings motif of molecules. The antioxidant test using the DPPH method showed that the compound exhibits a good antioxidant activity of about 80%. Atlanta Publishing House LLC 2024-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/2607 10.5155/eurjchem.15.4.320-324.2607 European Journal of Chemistry; Vol. 15 No. 4 (2024): December 2024; 320-324 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2607/2869 https://www.eurjchem.com/index.php/eurjchem/article/view/2607/2857 Copyright (c) 2024 Hamza Milad Ahmed Abosadiya https://creativecommons.org/licenses/by-nc/4.0