2026-05-31T01:31:54Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/2727 2026-03-31T05:13:14Z eurjchem:ART driver

Cs2CO3-mediated facile synthesis, characterizations, and biological activities of 4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ylidene)acetonitrile derivatives Patil, Atul Shivaji Patil, Raosaheb Shivaji Mahulikar, Pramod Pandurang Sadawarte, Gautam Prabhakar Rajput, Jamatsing Dabarsing Cs2CO3 2H-Pyran-2-one Antioxidant activity Pyrimidin-4-ylidene Ring transformations Antimicrobial activity In this study, we report the newer method for the synthesis of 4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ylidene) acetonitrile and the biological activities of the derivatives were systematically evaluated. The antimicrobial potential of the compounds was assessed against three bacterial and three fungal strains using the agar diffusion method. Among the derivatives tested, compounds 3b, 3e, and 3h demonstrated notable antibacterial and antifungal activities. Furthermore, the antioxidant capacity of the selected compounds was investigated through the DPPH radical scavenging assay. Compounds 3e and 3f exhibited significant radical scavenging activity, achieving effective inhibition at a concentration of 0.1 mg/mL. These findings highlight the promising antimicrobial and antioxidant properties of the investigated thiazolopyrimidine derivatives and support their potential for further biological and pharmacological studies. Atlanta Publishing House LLC 2026-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2727 10.5155/eurjchem.17.1.13-18.2727 European Journal of Chemistry; Vol. 17 No. 1 (2026): March 2026; 13-18 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2727/2993 Copyright (c) 2026 Atul Shivaji Patil, Raosaheb Shivaji Patil, Pramod Pandurang Mahulikar, Gautam Prabhakar Sadawarte, Jamatsing Dabarsing Rajput https://creativecommons.org/licenses/by-nc/4.0