2026-10-01T16:02:36Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/2798 2026-09-30T06:12:07Z eurjchem:ART driver

Synthesis and biological evaluation of an indanone-pyrazoline hybrid compound and its synthetic intermediates Nazir, Rabia Arshad, Muhammad Ifzan Chalcone Indanone Pyrazoline Schiff base Antimicrobial activity Agar diffusion method Pyrazoline and indanone scaffolds are two important skeletal motifs widely used in medicinal chemistry for their broad biological activities. In the current investigation, a novel indanone-pyrazoline hybrid compound was prepared in a three-step synthetic sequence. Synthesis consisted of the formation of a Schiff base via reaction with indanone, Claisen-Schmidt condensation to obtain the indanone chalcone, and phenylhydrazine cyclization to yield the desired pyrazoline. The synthesized compounds were evaluated using 1H NMR spectroscopy, while 13C NMR data were additionally obtained for compounds 1 and 3. Antimicrobial testing using the agar diffusion test produced inhibition zones of 11–12 mm against E. coli and S. aureus. The hybrid compound showed a 12 mm inhibition zone, whereas the intermediates produced an 11 mm inhibition zone; however, the biological relevance of this small numerical difference should be interpreted cautiously. For antifungal activity, C. albicans showed inhibition zones of 10–11 mm, with the Schiff base intermediate producing a slightly larger inhibition zone than the hybrid compound. At the same time, no inhibition was observed for A. flavus. Atlanta Publishing House LLC 2026-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2798 10.5155/eurjchem.17.3.239-243.2798 European Journal of Chemistry; Vol. 17 No. 3 (2026): September 2026; 239-243 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2798/3063 Copyright (c) 2026 Rabia Nazir, Muhammad Ifzan Arshad https://creativecommons.org/licenses/by-nc/4.0