2026-10-03T23:00:45Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/2811 2026-09-30T06:12:06Z eurjchem:REW driver

Applications of the Ritter reaction in the synthesis of biologically active compounds: A review Shevale, Reshma Bhanudas Waghmare, Smita Ravindra Nitriles Alcohol Amines Amides Inhibitors Ritter reaction Nitrogen-containing compounds play a fundamental role in biological systems. Proteins, the essential macromolecules responsible for virtually all cellular functions, are composed of amino acids linked through amide (peptide) bonds, highlighting the critical importance of nitrogen-containing functionalities in life processes. Ritter reaction methodologies have provided access to novel amide-containing scaffolds, which are valuable in medicinal chemistry and the creation of drug libraries. Ritter reactions are widely used in the synthesis of highly functionalized heterocycles, fused heterocycles and linear amides. These classes of compounds exhibit notable biological activities, including antibacterial, antiviral, antiproliferative, and anticancer activities. This review aims to compile recent advancements and applications of the Ritter reaction and mainly focuses on synthetic strategies for the synthesis of different classes of bioactive compounds. The evaluation of potential therapeutic applications of the most promising molecules synthesized using Ritter reaction is also covered in the present review. Atlanta Publishing House LLC 2026-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/2811 10.5155/eurjchem.17.3.289-318.2811 European Journal of Chemistry; Vol. 17 No. 3 (2026): September 2026; 289-318 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/2811/3069 Copyright (c) 2026 Reshma Shevale, Dr. Smita Waghmare https://creativecommons.org/licenses/by-nc/4.0