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oai:ojs.www.eurjchem.com:article/282 2011-06-30T10:44:15Z eurjchem:ART driver

Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives Mallesha, Lingappa Mohana, Kikkeri Narasimhasetty 1-(1 4-Benzodioxane-2-carbonyl)piperazine Antimicrobial activity Antioxidant activity Structure-activity relationship Sulphonyl chlorides Acid chlorides A series of novel 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives (6a-h) and (7a-e) were synthesized by nucleophilic substitution reaction of 1-(1,4-benzodioxane-2-carbonyl)piperazine (3) with various sulfonyl and acid chlorides. The newly synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, 1H NMR and LC-MS spectral studies. All compounds were evaluated for in vitro antibacterial, antifungal and antioxidant activities. Compound, 4-(2-trifluoromethyl)-benzenesulfonyl-1-(1,4-benzodioxane -2-carbonyl)piperazine (6b) exhibited significant antimicrobial activity against tested pathogenic bacterial and fungal strains. Compound, 4-(3-methoxy)-benzoyl-1-(1,4-benzodioxane-2-carbonyl)piperazine (7a) showed moderate antioxidant activity compared to standard drug by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay method. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/282 10.5155/eurjchem.2.2.193-199.282 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 193-199 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/282/PDF