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oai:ojs.www.eurjchem.com:article/289 2011-09-30T03:44:50Z eurjchem:ART driver

Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives Shabaan, Mohammed Taher, Azza Taher Osman, Eman Omar Quinoxaline 3 4-dihydroquinoxalin Antimicrobial activity CK1 inhibitors CDK5 inhibitors GSK-3β inhibitors New derivatives of 3,4-dihydroquinoxaline-2(1H)-one were synthesized and characterized. Representative examples were evaluated for their antimicrobial and antifungal activities using Tetracycline and Nystatin as reference compound. One of the tested compounds 10a was found to exhibit slight activity against Staphylococcus aureus. Compounds 10b, 11b and 14b showed slight activity against Escherichia coli. Moreover, nineteen compounds were screened for their inhibition effect on CDK5, CK1, and GSK-3β. None of the tested compounds showed an inhibition activity below 10 µM concentration. Atlanta Publishing House LLC 2011-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/289 10.5155/eurjchem.2.3.365-371.289 European Journal of Chemistry; Vol. 2 No. 3 (2011): September 2011; 365-371 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/289/PDF