2026-05-10T06:42:07Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/319 2011-09-30T03:44:50Z eurjchem:ART driver

Synthesis and antitumor activity of novel pyrazolo[1,5-a]pyrimidine derivatives El-Enany, Mervat Mostafa Kamel, Mona Monir Khalil, Omneya Mahmoud El-Nassan, Hala Bakr Pyrazole 5-Aminopyrazole Pyrazolo[1 5‐a]pyrimidine Antitumor activity Cytotoxic activity HCT116 A novel series of pyrazolo[1,5-a]pyrimidine-3-carbonitriles substituted with 7-amino, 7-substituted amino and 5-substituted amino groups was synthesized. Some of the newly synthesized compounds were tested in vitro on human colon tumor cell line (HCT116). Compound 14a displayed the highest activity among the tested compounds with IC50 that equals to 0.0020 μM. Atlanta Publishing House LLC 2011-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/319 10.5155/eurjchem.2.3.331-336.319 European Journal of Chemistry; Vol. 2 No. 3 (2011): September 2011; 331-336 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/319/PDF