2026-05-07T03:02:38Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/394 2011-06-30T10:44:15Z eurjchem:ART driver

Novel approach for preparing nontoxic stealth microspheres for drug delivery Angra, Pawan Kumar Rizvi, Syed Asad Ali Oettinger, Carl William D’Souza, Martin Joaquim Stealth microspheres Bovine serum albumin Cross-linked albumin Polyethylene glycol 2000 Spray drying Polymers Polyethylene glycol 2000 (PEG) entrapped, bovine serum albumin (BSA) microspheres were prepared and optimized. These microspheres were then analyzed to understand the stealth effect to the microspheres imparted by incorporated polyethylene glycol (PEG). Microsphere preparations (formulations) were studied for particle size, zeta potential, free BSA content, and in-vitro uptake by human micro-vascular endothelial cells (HMECs). The results demonstrate, a formulation containing 37.5 % PEG (w/w) exhibits an acceptable particle size of <5 µm, good suspendibility with zeta potential of -35 mV, and confers some degree of stealth property to the microspheres. These non-toxic, biodegradable and long circulating microspheres have the potential to be used for extended intravenous (IV) drug delivery. Statistical analysis done by ANOVA and results with p<0.05 were considered significant. Atlanta Publishing House LLC 2011-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/394 10.5155/eurjchem.2.2.125-129.394 European Journal of Chemistry; Vol. 2 No. 2 (2011): June 2011; 125-129 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/394/PDF