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Synthesis and preliminary biological screening of certain 5-aralkyl pyrrolidine-3-carboxylic acids as anticonvulsants Aboul-Enein, Mohamed Nabil El-Azzouny, Aida Abd El-Sattar Saleh, Ola Ahmed Nawwar, Mahmoud Abd El-Moien Ismail, Mohamed Abd El-Hamid Elsedeek, Mahmoud Gamal El-Din Maklad, Yousreya Aly Synthesis 5-aralkyl pyrrolidine-3-carboxylic acids Epilepsy Anticonvulsants Synthesis of a series of 5-aralkyl pyrrolidine-3-carboxylic acid derivatives namely, 1-acetyl-4-hydroxy-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (3a-e), 1-H-4-hydroxy-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (4a-e), 1-acetyl-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (8a-e), 1-H-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (9a-e) have been accomplished. The structures of the new compounds were assigned from IR, 1H NMR, 13C NMR and elemental analyses. Compounds 3a-e, 4a-e, 8a-e and 9a-e were biologically screened for their anticonvulsant potential using the subcutaneous pentylenetetrazole seizures (scPTZ) assay and Gabapentin as reference standard. The 1-H-4-hydroxy-5-benzyl or 5-(4-alkoxy-benzyl)-pyrrolidine-3-carboxylic acids (4a-e) showed the highest anticonvulsant activity. Compound 4b was found to be the most potent one which exhibited 100% protection. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/47 10.5155/eurjchem.1.2.102-109.47 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 102-109 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/47/PDF