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oai:ojs.www.eurjchem.com:article/523 2012-03-31T06:42:45Z eurjchem:ART driver

Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities Ahmad, Mohammed Rayees Sastry, Vedula Girija Prasad, Yejella Rajendra Khan, Mohammed Haseebur Rahman Bano, Nasreen Anwar, Syed Chalcones Pyrimidines Cytotoxic activity Microwave assisted Coventional method Antioxidant activity Pyrimidine is the parent substance of a large group of heterocyclic compounds and plays a vital role in many biological processes. It is also evident from literature; pyrimidines possess potential anti oxidant activities and cytotoxic activities. Chemoprotection by pyrimidines may be a consequence of their antioxidant properties, mediated via inhibition or induction of metabolic enzymes, by an anti-invasive effect or a reduction in nitric oxide production.  Free radicals are formed constantly in human system either as accidental products during metabolism or deliberately during the process of phagocytosis; or due to environmental pollutants, ionizing radiations, ozone, heavy metal poisoning, etc. Therefore, it is worthwhile to synthesize some pyrimidine derivatives by conventional and microwave (Catalyst systems) assisted synthesis methods. The synthesized compounds were purified by recrystallization or by chromatography and are characterized by 1H NMR, 13C NMR and IR analysis. The compounds were tested for their potential cytotoxic activity and antioxidant activities by standard methods. The microwave irradiation method (MWI) is proved to be advantageous with considerable increase in the reaction rate with better yields, after over all observation it is found  that pyrimidine derivatives possessing cytotoxic and anti-oxidant activities. Atlanta Publishing House LLC 2012-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/523 10.5155/eurjchem.3.1.94-98.523 European Journal of Chemistry; Vol. 3 No. 1 (2012): March 2012; 94-98 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/523/PDF